While the polysaccharides play a more important role for its antibacterial activity, the major antiviral constituents of Ganoderma species are both polysaccharides and triterpenoids. There appears to be a structure–activity relationship for triterpenoid-mediated antiviral effect.
The mechanisms for the antibacterial and antiviral activities of Ganoderma Lucidum and other Ganoderma species are largely undefined. Ganoderma constituents (e.g., polysaccharides and triterpenoids) may inhibit viral replication by interfering with their absorption, virus-hepatocyte fusion and endocytosis, also viral integration, assembly, and release. Currently available data suggest that Ganoderma lucidum and some other Ganoderma species plays a prominent role for the management of various infectious diseases.
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